Funding Acknowledgement: This project is funded by the National Institute for Health Research (NIHR) HTA programme (project reference 17/95/03).
Department of Health Disclaimer: The views and opinions expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.
Bristol Randomised Trials Collaboration acknowledgement: This study was designed and delivered in collaboration with the Bristol Randomised Trials Collaboration (BRTC), a UKCRC registered clinical trials unit (CTU) which, as part of the Bristol Trials Centre (BTC), is in receipt of National Institute for Health Research CTU support funding.
Sponsor acknowledgement: This study is sponsored by North Bristol NHS Trust (United Kingdom [UK]).
Please note: The content of this website is produced from PURSUIT documentation which has been reviewed by the Health Research Authority and ‘South West – Frenchay Research Ethics Committee’, who have provided approval for this study to be conducted in the NHS.